|
Macrophages (CD68) |
2 |
|
Proliferating cells (Ki-67) |
|
FDC-network (FDC-M2) |
|
|
Parameter |
Parameter description |
Calculation formula |
D |
areat |
Total GC area [μm2] |
|
D |
areat |
Total GC area [μm2] |
|
D |
areaLZ
|
Area of GC light zone [µm2]
|
|
D |
nKit
|
Total number of Ki-67+ cells
|
|
D |
nKiLZ
|
Number of Ki-67+ cells in GC light zone
|
|
D |
nTp+LZ
|
Number of CD3+ Ki-67+ proliferating T cells in GC light zone
|
|
D |
nMLZ
|
Number of CD68+ macrophages in GC light zone
|
|
D |
nMDZ
|
Number of CD68+ macrophages in GC dark zone
|
|
|
|
|
|
d |
areaDZ
|
Area of GC dark zone [µm2]
|
= areat - areaLZ
|
d |
nKiDZ
|
Number of Ki-67+ proliferating cells in GC dark zone
|
= nKit - nKiLZ
|
d |
nMt
|
Total number of CD68+ macrophages
|
= nMLZ + nMDZ
|
D, direct quantity; d, derived quantity
|